Research into conolidine has triggered discovery of an opioid receptor in the human body termed ACKR3/CXCR7. ACKR3 appears to be the most wanted focus on for conolidine, which also disregards one other four classical opioid receptors(3). **This is the subjective assessment according to the strength in the available informations https://bookmarkingbay.com/story20808541/considerations-to-know-about-alternative-natural-pain-relief-to-replace-traditional-painkillers