Below, we exhibit that conolidine, a organic analgesic alkaloid used in traditional Chinese drugs, targets ACKR3, therefore offering extra proof of the correlation involving ACKR3 and suffering modulation and opening option therapeutic avenues to the cure of chronic discomfort. We demonstrated that, in contrast to classical opioid receptors, ACKR3 https://www.proleviate.com/post/conolidine-for-pain-relief